Licor 43 is a Spanish liqueur, in fact, the most famous and best-selling Spanish liqueur in the world. Although often perceived as a vanilla liqueur, it actually contains 43 different spices, aromatic botanicals, and citrus fruits. Its name is derived from this fact. The reason it’s classified as a vanilla liqueur is because vanilla is dominant among these flavors. However, you can also taste the other flavors quite well. These distinct flavors actually make this liqueur quite versatile in cocktails. It’s commonly used with coffee, and in fact, in Mexico, one of the countries where it’s the most famous, the Carajillo (43) cocktail, a mix of espresso and liqueur, is so famour.